Dr. Sado is a blood thirsty serial killer psychiatrist who lures hapless victims into her office lair via advertisements in smutty magazines. To assist in her perverted and horrific crimes are a weird cabal of mostly incompetent henchpersons who constantly stoke tension with their bungling.

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The successful doctor Yoo Sepoong becomes entangled in a conspiracy and is kicked out of the palace. He meets Jihan in Gyesu village and learns to treat those who suffer psychological illness. Finding the cause of their heartbroken feelings and writing a prescription for happiness with Eunwoo, Sepoong grows up as a true psychiatrist.